Biopharmaceuticals

Biopharmaceuticals Companies (153)

Biopharmaceuticals News

Biopharmaceuticals Products (369)

  • Product HMG/Menotrophin for Injection BP 75 IU -Humenotropin HP 75 IU

    Human Menopausal Gonadotrophin 75 IU (lyophilized, sterile powder), & .0 ml Sodium Chloride Injection. This medication is used to treat certain fertility problems in women. It provides follicle stimulating hormone (FSH) and luteinizing hormone (LH) that help stimulate healthy ovaries to make eg...
  • Product FSH/Urofollitropin for Injection BP 75 IU - Ovitropin FSH 75 IU

    Urofollitropin is a human follicle-stimulating hormone (FSH) analogue that is used to treat infertility in women. Available as combipack of Urofollitropin for Injection BP 75 IU & Sodium Chloride Injection BP 0.9%w/v

  • Product Mobius® Breez Microbioreactor System

    The Mobius® Breez Microbioreactor is a 2 mL automated single-use perfusion cell culture platform designed to support gentle, adaptable, and reproducible cell processes. The system is capable of accelerating cell line development, media screening and optimization, and early process development
  • Product Protein stabilizer portfolio

    Specifically developed for high-risk applications, our portfolio of high-quality sugars, polyols, amino acids, and surfactants simplifies selection when you face critical challenges such as preventing aggregation during manufacturing.
  • Product Biologic drug substance CDMO services

    From pre-clinical development to commercial supply, Patheon by Thermo Fisher Scientific is an industry leader in the development and manufacture of mammalian cell culture drug substances. Patheon offers biotech and pharmaceutical companies the ability to pursue opportunities around the globe with a fully i...
  • Product Life Cycle Services

    Catalyx is a trusted partner in delivering world-class lifecycle services to regulated and high-risk end markets. With a relentless commitment to innovation and excellence, we partner with life science and other highly regulated organisations, to empower them to enhance efficiency, and drive success.&...
  • Product HEPAROSAN

    Building on the success of hyaluronic acid, HTL now wants to bring heparosan to market. Heparosan is a promising new biopolymer for the design of innovative medical and pharmaceutical devicesHeparosan is a glycosaminoglycan, a natural biopolymer, produced by HTL from substances of non-animal origin. H...
  • Product Peptide and Protein Technology

    Almac’s peptide and protein technology offering is a key component within our suite of services.  We offer a complete range of peptide and protein services from catalogue products through to GMP manufacture from early phase to commercial launch.  We have a proven track record in high quality supp...
  • Product Biologic Quality Control and Release Testing

    We deliver responsive QC analysis for complex biologic products from our cGMP laboratories. Our scientists develop and validate methods or perform technology transfer of a sponsor's method for a wide range of analytical methods required for batch release testing. We also routinely carry out testing to Phar...
  • Product Trypsin

    Trypsin, a digestive proteolytic enzyme cleave peptide bonds specifically at the carboxyl end of the lysine and arginine residues.Recombinant trypsin, animal-derived component free, compliance with the pharmacopoeia standards,

    We offers different formulations including lyophilizate and liquid pr...
  • Product Azelaic Acid

    Usage:

    1. Industrial:

    (1)It is an additive in the production of complex lithium base grease;

    (2)The raw material for the production of plasticizer;

    (3)It can be used as an intermediate in some new coatings, polyurethane, nylon industry;

    (4)It is a...
  • Product Primary Packaging for IV-solution bags

    PolyCine offers:

    Primary Packaging Films for IV-solution bag
    Filling and transfer tubes for Primary Packaging
    Hot Foils for IV-solution bag / primary container printing
    Compounds for Primary Bag Connectors & Ports

  • Product Single-Use Assemblies

    Whether you are looking for an economical standard single-use system or require a custom-designed and built single-use system, we can offer a proven solutions at every scale.

    With a wealth of experience, knowledge, and solid quality processes behind every single-use product, we strive to assure ...
  • Product Acid red 87 (eosin y ws , c.i.45380)

    Macsen laboratories offers a wide range of products which includes acid red 87 (eosin y ws, c.i.45380). It belongs to Speciality dyes and biological stains category. Applications: acid red 87 also known as eosine is used mainly as a dye for various industrial, cosmetic & scientific applications. Contact u...
  • Product Aramus™ 2D Bag Chambers from Entegris

    These high-performance fluid storage and transfer bag chambers are made of a high-grade, gamma-stable fluoropolymer that provides high purity, exceptional compatibility and increased safety for critical process fluids and high-value final products. They also have a wide operating temperature range of -...
  • Product Mineral Phosphates

    Dr. Paul Lohmann® offers a wide range of Mineral Phosphates for the Biopharmaceutical industry. They are widely used in various processes such as upstream, downstream and drug formulation and are an essential part of the entire biomanufacturing process. We also offer buffers as solid premixes or readily...
  • Product NABOTA®

    Botulinum toxin type A  
    Indication: Glabella Lines (Approved in KR, US, CA, EU), Post Stroke Upper Limb Spasticity, Crow's feet, Blepharospasm, Benign Masseteric Hypertrophy (Approved in KR)
    - Nabota is the only 900kDa Neurotoxin approved in the US and EU since Botox.- It has demonstra...
  • Product Cell Culture Services

    FUJIFILM Diosynth Biotechnologies is a leading provider of cell culture services for biologics, advancing anddelivering life changing therapies. We offer complete solutions for cell line development, process development, late phase activities, clinical and commercial manufacturing of a wide variety of biop...
  • Product 4000-LC Series Controller Rate Chamber

    FARRAR™ pioneered forced air convection cooling to answer the challenge of preserving biologic samples and materials. The Controlled Rate Chamber (model 4000-LC series) features a 12-inch HMI screen with graphical display of chamber and product temperature. The unit provides repeatable, precise, ...

Biopharmaceuticals

Biopharmaceuticals, also known as biologic medical products, are drug products manufactured using biotechnology. Biopharmaceutical drugs are structurally similar to various compounds within the body. Over time, drug development has progressed from small-molecule compounds to large molecule proteins and other accompanying biopharmaceuticals. The discovery of biopharmaceuticals has significantly improved the healthcare delivery. It has provided a shift in providing cures for chronic illnesses such as refractory cancers, diabetes, autoimmune diseases, etc., thereby improving the affected patients' quality of life.

The use of biopharmaceuticals for therapeutic purposes dates as far back as the 19th century, with recombinant human insulin being the first approved biopharmaceutical used for therapeutic purposes in human beings. Over the last three decades, the biopharmaceutical industry has experienced notable growth and is expected to contribute to some remarkable pharmaceutical industry developments. Biopharmaceutical offers a wide range of advantages and benefits to pharmaceutics, and here, we would be exploring these benefits. We would also examine the biopharmaceutical manufacturing process, notable examples of biopharmaceuticals, and more.

What are biopharmaceuticals?

These complex medicines are proteins (monoclonal antibody), sugars (glycan), nucleic acids (RNA, DNA), living cells, or tissues extracted or semi synthesized from a biologic source by biotechnology for in vivo diagnosis or therapeutic purposes.

The majority of biopharmaceuticals are synthesized or derived from living organisms or genetically modified cells and organisms. They cannot only lessen symptoms or treat chronic diseases but also cure them with little or no side effects because of their origin and specificity. Some biopharmaceuticals include enzymes, antisense drugs, cytokines, monoclonal antibodies, gene therapy, cell therapy, etc.

Biopharmaceuticals have helped personalize the treatment process to meet the specific health needs of patients. This is achieved through the modification of drugs genetically through DNA-recombinant technologies or cell fusion to alter specific factors to cure, prevent, or diagnose individual diseases.

How are biopharmaceuticals made, and why?

As opposed to chemical synthesis through which conventional medicines and drug products are made, biopharmaceutical drugs are synthesized through more complex processes from living cells. With the rapid growth of the biopharmaceutical industry and the discovery of new biologic therapies, the term biopharmaceutical (biologics) refers to a variety of medicines and drug products. The diversified portfolio contains various drugs produced by different biotechnological methods and techniques.

These drug products are not made from chemical mixtures but rather from living organisms. Experts in cellular biology, biochemistry, and several other fields carry out biologic testing and analysis (using analytical methods) to ensure that the desired end product is made.

For example, biologics used to treat joint pain are made by adding a DNA into a living cell such as a yeast or mammalian cell to enable the production of a specific molecule in large amounts. These molecules are usually therapeutic proteins that are isolated and utilized as active ingredients.

When newly introduced, biopharmaceuticals focused solely on developing recombinant protein such as enzymes (TPA) and hormones (insulin, erythropoietin, growth hormone, etc.) through recombinant DNA techniques. With time, they have delved into the design and development of chemically defined cells, manufacturing of monoclonal antibodies, and genome-based technology. These new techniques have improved the pharmaceutical manufacturing process and created new treatment options for different diseases.

Like every other drug, biopharmaceutical drugs are produced for therapeutic purposes, but with a catch. They are produced majorly to cure chronic and dilapidating diseases such as cancer, diabetes, rheumatoid arthritis, and several others. The manufacturing of these drug products also aims at providing effective, safe, and cost-effective drugs for therapeutic purposes.

What is the biopharmaceutical industry?

The biopharmaceutical industry is an essential subset of the pharmaceutical industry. It is comprised of biopharmaceutical companies that discover, develop, produce, and market biopharmaceuticals. The drug products made are used to diagnose, treat, prevent, and cure diseases when administered to patients. This industry deals majorly in biopharma drugs and medicines produced via the biotechnological process from living entities such as micro-organisms, living cells, tissues, or organs of humans and animals. The biopharmaceutical industry successfully merges between biotech and pharmaceutical companies to provide better and safer healthcare to patients.

What is the difference between biopharmaceutic and biopharmaceuticals?

Biopharmaceutics is simply pharmaceutics that deals with biopharmaceuticals. It is a branch of pharmaceutical science that examines the physiochemical properties of drugs, their toxicology, pharmacology, dosage forms, and patients' clinical response to drugs, biopharmaceuticals inclusive. The recommended dosage and dosing interval varies for different drugs, and it significantly affects their efficacy and safety. Biopharmaceutics provide adequate information and understanding of the pharmacodynamics and pharmacokinetics of biopharmaceutical drugs, their metabolites, and their effects on the body. Through biopharmaceutics, biopharmaceutical drugs can be evaluated based on their properties and effects on the body.

On the other hand, biopharmaceuticals refer to inherently biologic pharmaceuticals extracted, synthesized, or semi-synthesized from live forms using biotechnological methods. They constitute a significant part of the drug products examined and evaluated in biopharmaceutics to improve healthcare delivery and, in turn, the quality of patients' lives.

How are biopharmaceuticals manufactured?

The rapid advancement of genetics and molecular biology has played a significant role in the biopharmaceutical manufacturing process. The introduction of new and refined techniques such as protein purification, host system, etc., has positively impacted the efficacy, capacity, and safety of biopharmaceuticals produced.

There are many biopharmaceutical manufacturing processes, and they vary based on the type of drug product to be produced.

Where is biopharmaceutical manufacturing heading?

With several emerging technologies in the biopharmaceutical manufacturing process, the biopharmaceutical manufacturing process is expected to take a huge turn. With over 1000 biopharmaceuticals in clinical trials, the majority of drugs in the future may be biopharmaceuticals. The increased need for biopharmaceuticals and the constant advancement in biotech will impact biopharmaceutical manufacturing. Given the various advantages of gene therapy, biopharmaceuticals' manufacturing process is likely to focus more on gene therapy in the future.

What is the process involved in the process of manufacturing biopharmaceuticals?

The process of small-scale and large-scale biopharmaceutical production varies. However, biopharma companies produce to indulge in large-scale biopharmaceutical production. The processes involved in manufacturing these drugs are complex, lengthy, and largely differ depending on the end-product. Generally, the processes include biosynthesis, purification, formulation, and final dosage preparations.

Materials and equipment are sterilized at the biosynthetic stage, and a cell culture or biologic extract is harvested or collected in a bioreactor to grow and multiply. During the purification process, cells, tissues, enzymes, or desired products are separated from surrounding nutrients and byproducts to produce the bulk product. Unlike conventional drugs mixed with other chemical components during formulation, biopharmaceuticals are made and sold as sterile products. Although they are sold as sterile products, biopharmaceuticals are packaged in similar ways as conventional drugs before distribution and sales.

This description gives a general knowledge of the manufacturing process carried out. Nevertheless, there are special intricate biotech processes that can be carried out and some include continuous manufacturing, and other processes requiring single use technology.

What special considerations must be made when manufacturing biopharmaceuticals?

Consistent safety, effectiveness, and quality are the essential factors that must be considered during the biopharmaceutical manufacturing process.

The manufacturing processes of each biopharmaceutical product must be designed to produce consistent quality and safe biopharmaceutical drug products. This involves the complete removal of contaminants and impurities such as viral contamination, endotoxins, cell membranes, and others from the separated product. Also, regular rigorous and well-documented checks and examinations on the efficiency and performance of the materials and equipment must be carried out to validate the manufacturing process.

Benefits of biopharmaceuticals

Given the structural composition and origin of biopharmaceuticals, these bio drugs provide several health benefits to patients and, in extension, the healthcare industry and healthcare professionals. The emergence of biopharmaceuticals has provided patients with a better shot at quality life and longevity.

How do patients benefit from biopharmaceuticals?

Biopharmaceutical drugs, unlike conventional medicines, mimic the structures of human compounds, and this gives biopharmaceuticals the potential and ability to cure diseases more effectively. They also produce fewer side effects due to their high specificity, unlike the traditional medications that are capable of affecting multiple systems simultaneously. Given their similarities with human compounds, they are very safe and highly effective.

Also, these drugs can be genetically modified to allow healthcare professionals to tailor treatments to meet patients' specific health needs. In addition, some generic drugs play crucial roles in providing patients with curative and diagnostic benefits.

However, one of the greatest potentials of biopharmaceuticals that also serves as an essential benefit to patients is gene therapy. Through gene therapy, conditions characterized by rapidly dividing cells due to mutated or defective genes, such as cancer, can be cured. Unlike some cancer drugs and other medications also, biopharmaceutical drugs are non-carcinogenic. The innovation of biopharmaceuticals also aids in producing varieties of vaccine to prevent infection and the spread of infectious diseases in patients.

Generally, bio drugs improve longevity, increase life expectancy, provide welfare to the population, and provides several public health benefits.

How does the healthcare industry benefit from biopharmaceuticals?

The impact of biopharmaceuticals and biopharmaceutical innovation on health care professionals also tells on the healthcare industry. Biopharmaceuticals have a massive positive economic impact, and other healthcare industry benefits that cannot be ignored. The development and availability of the various biopharmaceuticals in the pharmaceutical market will increase access to bio drugs, cost-effective medicines, and a boost in the global pharmaceutical market. Also, the ease of commercial production of biopharmaceuticals boosts the healthcare industry's economy and market growth.

How do healthcare professionals benefit from biopharmaceuticals?

Biopharmaceuticals and biopharmaceutical innovations provide outstanding benefits to healthcare professionals. It provides healthcare professionals with a variety of safe and efficient curative and therapeutic options for their patients. Therefore, in cases where a particular bio drug doesn't produce the desired therapeutic effect in a specific patient or has undesired side effects, other alternatives within the same drug family can be administered. Also, biopharmaceutical innovation provides job opportunities for healthcare professionals and individuals in different fields of practice.

Examples of common biopharmaceuticals

There are various biopharmaceutical products, and the majority of these products are widely known. Some common biopharma products include insulin, blood factor IX and VIII, human growth hormone, erythropoietin, tissue plasminogen activator, therapeutic antibodies, glucocerebrosidase, interferon α, and β, and GSCF. These form the most common examples, but they fall into the different biopharmaceutical classes, including hormones, clotting factors, blood products, vaccines, cytokines, and growth factors.

Where can some common biopharmaceuticals be found?

Biopharmaceuticals are derived and produced from various cells. They can be extracted and synthesized mammalian cell lines, microbial cells (yeast culture or recombinant E. coli), moss plants, and plant cell cultures. The majority of these sources are readily available and accessible at all times. These sources are origins from which the drug development process spans.

Who commonly uses biopharmaceuticals?

Biopharmaceuticals are primarily used for patients. However, most of the patient population that uses biopharmaceuticals are patients with long-term diseases such as psoriasis, diabetes, Crohn’s disease, rheumatoid arthritis, etc. The elderly constitute the majority of patients affected by either of these chronic conditions. Also, cancer patients form a significant percentage of the patient population using biopharmaceutical products.

What industries can common biopharmaceuticals be found in?

The common biopharmaceuticals are produced majorly by the biopharmaceutical and biotechnology industries. Within these industries, these biopharmaceutical products are developed and manufactured by biopharmaceutical companies. Some of the top pharma companies that manufacture the most common biopharma products include Gilead Sciences, Amgen, Genentech, Biogen, Riotech, Samsung biologics, Teva Pharmaceuticals, Celgene, Pfizer, United Therapeutics Corporation, UCB, and Sanofi. Although these companies form the existing biopharmaceutical manufacturing companies, a new biopharmaceutical company, Clover biopharmaceuticals, presently undergoing clinical trial is set to become a top tier pharmaceutical company in this industry.

References

https://www.semanticscholar.org/paper/Biopharmaceuticals%3A-an-overview-Sekhon/3ca58f5a3353b8a962035aa855995ce64a8d7b8b

https://www.intechopen.com/books/basic-pharmacokinetic-concepts-and-some-clinical-applications/biopharmaceutics-and-pharmacokinetics

https://www.intechopen.com/books/basic-pharmacokinetic-concepts-and-some-clinical-applications/biopharmaceutics-and-pharmacokinetics

https://medcraveonline.com/OAJS/biopharmaceutical-innovation-benefits-and-challenges.html

https://ispe.org/pharmaceutical-engineering/may-june-2016/biopharmaceutical-manufacturing-process-validation-and

https://www.google.com/amp/s/www.microfluidics-mpt.com/blog/how-are-biopharmaceuticals-produced%3fhs_amp=true

References

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